Inherited and acquired thrombophilia as a modifier of clinical course of chronic immune thrombocytopenia
نویسندگان
چکیده
منابع مشابه
Inherited and Acquired Thrombophilia in Pregnancy
The thrombophilia represent a spectrum of coagulation disorders associated with a predisposition for thrombotic events (deep vein thrombosis (DVT) and pulmonary embolism (PE)) (Kaandorp et al, 2009). Inherited thrombophilia include a single-point mutation on the Factor V gene (factor V Leiden (FVL), prothrombin (PT) G20210A gene mutation, deficiencies in protein C and protein S as well as antit...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Impact of immune thrombocytopenia on the clinical course of chronic lymphocytic leukemia
The prevalence, clinical characteristics, and prognostic significance of immune thrombocytopenia (IT) in patients with chronic lymphocytic leukemia (CLL) have not been clearly determined. To clarify this, we retrospectively analyzed 1278 consecutive newly diagnosed patients with CLL. Criteria for IT diagnosis included the following: rapid (< 2 weeks) and severe fall (half of the initial level a...
متن کاملInherited Genetic Markers for Thrombophilia in Northeastern Iran (a Clinical-Based Report)
Background: Thrombophilia is a main predisposition to thrombosis due to a procoagulant state. Several point mutations play key roles in blood-clotting disorders, which are grouped under the term thrombophilia. These thrombophilic mutations are methylenetetrahydrofolate reductase (MTHFR, C677T, and A1298C), factor V Leiden (G1691A), prothrombin gene mutation (factor II, G20210A), and plasminogen...
متن کاملInherited thrombophilia: pathogenesis, clinical syndromes, and management.
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متن کاملPregnancy and Issues with Inherited and Acquired Thrombophilia
Pregnancy is hypercoagulable state. The field of thrombophilia; the tendency to thrombosis, has been developed rapidly and has been linked to many aspects of pregnancy. It is recently that severe pregnancy complications such as severe preeclampsia, intrauterine growth retardation, abruptio placentae and stillbirth has been shown to be associated with thrombophilia. Recurrent miscarriage has als...
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ژورنال
عنوان ژورنال: Journal of Applied Hematology
سال: 2020
ISSN: 1658-5127
DOI: 10.4103/joah.joah_75_19